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Pain is an “unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” []. Mesotherapy, commonly known as "biorejuvenation" or "biorevitalization", is a technique used to rejuvenate the skin by means of a transdermal injection of a multivitamin solution and natural plant. 00The Meso Power Device MS-3 is a sophisticated and safe device for clinical microneedling and non-invasive mesotherapy. You may also have heard this treatment referred to as the V2 Beauty Booster or a liquid facial. We aim to perform a systematic review to analyze scientific literature with the purpose of comparing efficacy and adverse effects of both administration routes. 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